Enzymes in Drug Development
Enzyme in der Arzneimittelentwicklung
6 LPWiSeEN
Inhalte
• Enzyme structure, function, and kinetics • Enzymes as drug targets: identification and validation • High-throughput screening methods for enzyme inhibitors • Structure-based drug design targeting enzymes • Pharmacokinetics and drug metabolism: role of metabolizing enzymes • Enzyme engineering for drug discovery and development • Prodrug strategies and enzyme-activated therapeutics • Drug-drug interactions mediated by enzymes • Emerging technologies in enzyme-based drug discovery
Lernziele
This module explores the critical role of enzymes in drug discovery and development, providing students with a comprehensive understanding of how enzymes function as both targets and tools in pharmaceutical research. The course will cover fundamental concepts of enzymology and their practical applications in drug design, screening, and optimization.
Prüfungsleistung
Prerequsite: • Successful completion of the seminar including a 30 min presentation and 15 min discussion Final Module Examination: • Final written examination (120 min)
Literatur (2)
- "Enzymes and Their Inhibitors: Drug Development" edited by H. John Smith and Claire Simons
- "Opportunities for Accelerating Drug Discovery and Development by Applying Engineered Drug-Metabolizing Enzymes" by Guo-Qiang Chen, published in Drug Metabolism and Disposition
Quelle: Modulbeschreibung der BTU · abgerufen 16.10.2026Original